Treating Melasma Precisely Using The 350Ps TruePico Laser Device

Feb 04, 2026

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Melasma is a painless but persistent condition that affects patients' appearance and mood, making the safe and effective removal of melasma a question many people want answered.

 

For years, traditional methods have often fluctuated between "improvement" and "recurrence," and "effectiveness" and "risk," sometimes even worsening the condition due to improper stimulation. However, with the rapid evolution of laser technology, the treatment of melasma has ushered in more precise and advanced solutions. Among them, the 350Ps TruePico laser technology, with its unique ultra-short pulse width and precise photoacoustic mechanism, provides a brand-new, highly effective ideal solution for the treatment of melasma.

 

To understand why the 350Ps TruePico laser is so effective in removing melasma, it is first necessary to understand the nature of melasma.

 

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is a common but harmless skin condition that mostly occurs on sun-exposed areas of the face, resulting in dark discoloration due to excessive pigmentation. If you have melasma, you will notice brown or grayish-brown patches on your face, usually on the cheeks, forehead, nose, and chin. Melasma is sometimes also called "pregnancy mask" and is common in female patients, especially during pregnancy or when taking birth control pills.

 

 

Traditional views held that melasma was primarily located in the epidermis, but modern research has found that in most patients, melanin granules are active in both the epidermis and the superficial dermis, presenting as three types: "epidermal," "dermal," and "mixed." This multi-layered distribution is one of the reasons why traditional single therapies are often ineffective in eradicating melasma.

 

You can use a Wood's lamp to determine the type of melasma.

 
Appears dark brown with clear boundaries, clearly visible under a Wood's lamp, and sometimes responds well to treatment.

 
Appears light brown or blue with blurred boundaries, looks no different under a Wood's lamp, and responds poorly to treatment.

 
This is the most common type of melasma, exhibiting both blue and brown patches, showing a mixed pattern under a Wood's lamp, and having a moderate response to treatment.

 

 

 

How does the 350Ps TruePico laser work on melasma?

 

 

Traditional Q-switched nanosecond lasers (with pulse widths in the nanosecond range, i.e., one billionth of a second) primarily rely on "selective photothermal effect." Melanin absorbs laser energy and generates high temperatures, destroying the target through thermal diffusion. However, this thermal diffusion inevitably affects surrounding normal tissue, causing thermal damage. For fragile melasma-affected skin, this easily induces post-inflammatory hyperpigmentation, thus backfiring.


The 350Ps TruePico laser, however, has a pulse width shortened to the picosecond range (one trillionth of a second, only a fraction of a nanosecond). Within this extremely short time, the energy is instantly targeted at melanin with extremely high peak power, preventing the energy from being transferred to surrounding tissues through thermal diffusion. Instead, a "" occurs-the target pigment particles are shattered into extremely tiny dust-like particles through rapid thermal expansion and contraction. These tiny pigment particles are then naturally eliminated from the body through metabolism, achieving effective treatment of melasma.

 

 

 

Almost all of the laser energy is used to shatter melanin particles, resulting in minimal thermal damage to the surrounding skin tissue. This significantly reduces pain during treatment and, more importantly, greatly reduces the risk of inflammation and hyperpigmentation caused by thermal damage.

 

Melanin is shattered into finer "dust," making it easier for the body's macrophages to recognize, engulf, and eliminate it through the lymphatic system. This means that each treatment is more effective in reducing blemishes, improving treatment efficiency, and reducing the number of treatments required, making it ideal for those with busy schedules who want to remove melasma. If you own a clinic or beauty salon, this technology can help you increase daily customer traffic and customer retention rates.

 

 

 

Advanced 350Ps TruePico laser devices are typically equipped with multiple wavelengths (such as 532nm, 755nm, and 1064nm). Doctors can select the most suitable wavelength for precise targeting based on the depth of melasma pigmentation and the patient's skin type. For example:

 

  • 532nm : Provides excellent absorption of brown pigment in the superficial epidermis, effectively treating epidermal melasma.
  • 1064nm : Penetrates deeper, acting on pigment in the superficial dermis. Due to its absorption by hemoglobin, it can simultaneously target dilated capillaries in the melasma area, inhibiting the stimulation of melanocytes by vascular factors and intervening in the progression of melasma from the source.

 

 

 

Who are the ideal candidates for 350Ps TruePico laser treatment?

 

Although the 350Ps TruePico laser offers excellent results and experience for melasma treatment, it is not suitable for everyone. Therefore, a professional assessment is required before treatment to determine if you are a suitable candidate for picosecond laser treatment for melasma.

 

 

  • Patients evaluated by a professional physician: especially those who have responded poorly to traditional drug treatments, chemical peels, or conventional laser treatments, or those prone to hyperpigmentation.
  • Patients with epidermal and mixed-type melasma: This technology is highly effective in clearing epidermal pigmentation and also has a good effect on superficial dermal pigmentation.
  • Patients seeking highly tolerable treatments with short recovery times: Due to minimal thermal damage, treatment discomfort is mild, and post-treatment erythema and edema are mild and resolve quickly, without affecting normal social life.
  • Patients with Fitzpatrick skin types III-IV: With appropriate parameter settings, TruePico technology offers the highest safety for individuals with medium skin tones.

 

We mentioned above that some people can effectively treat melasma with 350Ps TruePico laser treatment, but there are also some people who are not suitable for this treatment.

 

  • Melasma in the active inflammatory phase: If the face is significantly red and sensitive, basic treatment to reduce inflammation and repair the skin barrier should be performed first. Laser intervention should only be considered after the skin has stabilized.
  • Those with recent sun exposure or very dark skin: Strict sun protection is required before treatment. For those with very dark skin (Fitzpatrick types V-VI), treatment parameters must be selected very carefully by an experienced physician.
  • Those with unrealistic expectations: It is essential to understand the long-term nature of melasma treatment. Laser treatment is only a key part of comprehensive management, not a one-time cure. After treatment, strict sun protection, the use of medical skincare products, and possible medication for maintenance treatment are necessary.
  • Pregnant and breastfeeding women: Currently, there is no scientific research proving that laser treatment is absolutely safe for pregnant women. Therefore, I recommend that pregnant and breastfeeding women postpone treatment, as health is the prerequisite for beauty.

 

 

 

Although we have learned about the superior performance and excellent efficacy of the 350Ps TruePico laser in treating melasma, for those who do not currently have melasma, it is necessary to take preventive measures in daily life if you want to avoid developing melasma on your face.

 

 

Apply a high-SPF sunscreen (SPF+++) daily, even on cloudy days.
Reapply sunscreen every two hours, and more frequently after swimming or sweating.


You can also use tinted sunscreens containing iron oxide to protect against visible light and prevent hyperpigmentation.


In addition to applying sunscreen, always wear a hat, sunglasses, and protective clothing for physical sun protection when outdoors.


Avoid direct sunlight as much as possible, especially between 10 AM and 4 PM.

sun protection

 


Avoid using harsh or highly irritating skincare products, chemical peels, or exfoliating scrubs, as these can trigger inflammation.


Use serums containing vitamin C or vitamin E, which help combat free radical damage caused by sun exposure.


Avoid high-temperature environments and limit your time in saunas, hot springs, and hot showers.


Minimize exposure to blue light emitted from screens, as it can damage the skin.

facial hydration

 

 

  • If you suspect oral contraceptives are causing melasma, discuss other non-hormonal or low-hormone birth control methods with your doctor.

 

  • Consult a dermatologist during pregnancy to manage hormone-induced skin changes.
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  • Are there any risks associated with 350Ps TruePico laser treatment for melasma?

We have followed up with many users who purchased our picosecond laser equipment, and they all reported excellent results with minimal side effects. Therefore, you can trust our technology and equipment. Furthermore, with the advancements in technology and medicine in recent years, the risk of side effects has been greatly reduced. As long as the procedure is performed correctly and you are not among the contraindicated groups, you can safely use this laser technology to remove melasma.

 

  • Besides melasma, what other skin conditions can the 350Ps TruePico laser treat?

is equipped with various laser heads, and in addition to effectively treating melasma, it can also address a variety of skin problems. For example, it can perfectly remove various colors of ink, including stubborn green and blue tattoos. Our laser equipment can effectively remove sunspots, age spots, and freckles, making your skin more radiant. In addition, it can improve overall skin texture, reduce pores, and give you a smoother and brighter complexion.

 

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